Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.33 |
| ▸ | PDE8A | O60658 | 4/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20606998 | 0.81 | MBOAT4 (0.36) | MBOAT4PDE8APDE2APDE4DKCNH2 | |
| SCHEMBL20607008 | 0.79 | PDE4D (0.39) | PDE4D | |
| SCHEMBL20607010 | 0.78 | MBOAT4 (0.34) | MBOAT4 | |
| SCHEMBL25364522 | 0.73 | HSP90AA1 (0.36) | — | |
| SCHEMBL30496052 | 0.73 | HSP90AA1 (0.36) | — | |
| SCHEMBL28247334 | 0.72 | HPGD (0.39) | MBOAT4PDE8A | |
| SCHEMBL30977446 | 0.70 | MBOAT4 (0.39) | MBOAT4 | |
| SCHEMBL20606997 | 0.69 | PDE8A (0.36) | PDE8APDE2APDE4DKCNH2PDE10A | |
| SCHEMBL31168015 | 0.69 | PDE8A (0.36) | PDE8APDE2APDE4DKCNH2PDE10A | |
| SCHEMBL29082185 | 0.68 | MBOAT4 (0.34) | MBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |
| EP-3423445-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | Galapagos NV (BE) | 2019-01-09 | — | — | EP | disclosed |