Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 2/20 | 0.36 |
| ▸ | ARG2 | P78540 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3326983 | 0.88 | LTA4H (0.40) | HRH3HTR2ALTA4HL3MBTL1SMN1; SMN2 | |
| SCHEMBL7133334 | 0.80 | SMN1; SMN2 (0.51) | HRH3KDM4ECYP2D6HTR2ALTA4H | |
| SCHEMBL2060737 | 0.79 | KCNH2 (0.51) | HRH3KCNH2KDM4ELTA4HSMN1; SMN2 | |
| SCHEMBL19514340 | 0.78 | LTA4H (0.47) | HRH3KDM4EHTR2ALTA4HL3MBTL1 | |
| SCHEMBL396677 | 0.77 | KCNH2 (0.61) | KCNH2SMN1; SMN2 | |
| SCHEMBL14012818 | 0.77 | HRH3 (0.46) | HRH3KCNH2KDM4ECYP1A2CYP3A4 | |
| SCHEMBL3212052 | 0.77 | LMNA (0.41) | KDM4EL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL9493891 | 0.76 | KCNH2 (0.64) | KCNH2 | |
| SCHEMBL9492760 | 0.76 | KCNH2 (0.64) | KCNH2 | |
| SCHEMBL6216002 | 0.76 | KCNH2 (0.64) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148422-B2 | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-04-03 | — | — | US | disclosed |