Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323854 | 0.90 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTLMNATDP1 | |
| SCHEMBL6973109 | 0.82 | KCNH2 (0.55) | KCNH2ALDH1A1KDM4EHRH3MAPT | |
| SCHEMBL22301206 | 0.82 | KCNH2 (0.55) | KCNH2ALDH1A1KDM4EHRH3MAPT | |
| SCHEMBL6950591 | 0.82 | MAPT (0.55) | KCNH2ALDH1A1KDM4EHRH3MAPT | |
| SCHEMBL15569388 | 0.82 | MAPT (0.62) | KCNH2ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL27883912 | 0.81 | KCNH2 (0.54) | KCNH2ALDH1A1KDM4EHRH3MAPT | |
| SCHEMBL3212302 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTTDP1GAA | |
| SCHEMBL17598265 | 0.80 | MAPT (0.54) | KCNH2ALDH1A1KDM4EHRH3MAPT | |
| SCHEMBL1495915 | 0.80 | LMNA (0.54) | KCNH2ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL8316368 | 0.80 | HRH3 (0.58) | KCNH2ALDH1A1KDM4EHRH3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148422-B2 | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-04-03 | — | — | US | disclosed |