SCHEMBL20607622

SCHEMBL20607622

FC(F)(F)c1cc(-c2c(Cl)cccc2Oc2ncc(Br)cn2)on1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.35
▸ HPGD P15428 3/20 0.33
▸ KDM4E B2RXH2 3/20 0.33
▸ ALDH1A1 P00352 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ HSD17B10 Q99714 1/20 0.33
▸ BLM P54132 1/20 0.32
▸ NPSR1 Q6W5P4 2/20 0.32
▸ ATM Q13315 1/20 0.32
▸ CYP1A2 P05177 3/20 0.32
▸ CYP2C19 P33261 3/20 0.32
▸ L3MBTL1 Q9Y468 3/20 0.32
▸ CYP3A4 P08684 2/20 0.32
▸ CYP2D6 P10635 1/20 0.32
▸ EPAS1 Q99814 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ HSP90AA1 P07900 1/20 0.30
▸ HSP90AB1 P08238 1/20 0.30
▸ CASP3 P42574 1/20 0.30
▸ POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29780134 1.00 KMT2A (0.35) KMT2AHPGDKDM4EALDH1A1MEN1
SCHEMBL29780133 0.91 KMT2A (0.36) KMT2AHPGDKDM4EALDH1A1MEN1
SCHEMBL20558452 0.91 KMT2A (0.36) KMT2AHPGDKDM4EALDH1A1MEN1
SCHEMBL20607621 0.82 L3MBTL1 (0.30) KMT2AL3MBTL1POLBGAA
SCHEMBL29780132 0.82 L3MBTL1 (0.30) KMT2AL3MBTL1POLBGAA
SCHEMBL20607619 0.81 L3MBTL1 (0.34) KMT2AHPGDKDM4EALDH1A1MEN1
SCHEMBL29780136 0.81 L3MBTL1 (0.34) KMT2AHPGDKDM4EALDH1A1MEN1
SCHEMBL31403279 0.75 ALDH1A1 (0.36) KMT2AHPGDKDM4EALDH1A1MEN1
SCHEMBL16915376 0.74 ALDH1A1 (0.37) KMT2AHPGDKDM4EALDH1A1MEN1
SCHEMBL29780137 0.74 ALDH1A1 (0.37) KMT2AHPGDKDM4EALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4069680-B1 PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL FMC CORP (US) 2026-03-25 — — EP claimed
US-12516045-B2 Process for synthesis of a 2-thioalkyl pyrimidine FMC CORPORATION (US) 2026-01-06 — — US claimed
EP-3094631-B2 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES FMC CORP (US) 2024-12-25 — — EP claimed
US-20230068064-A1 PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE FMC CORPORATION 2023-03-02 — — US claimed
EP-4069679-A1 PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE FMC CORPORATION (US) 2022-10-12 — — EP claimed
EP-4069680-A1 PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL FMC CORPORATION (US) 2022-10-12 — — EP claimed
US-11447476-B2 Pyrimidinyloxy benzene derivatives as herbicides FMC CORPORATION (US) 2022-09-20 — — US claimed
CN-114761384-A Process for the synthesis of 2-thioalkyl pyrimidines FMC公司 2022-07-15 — — CN claimed
CN-114746406-A Method for synthesizing 2- (5-isoxazolyl) -phenol FMC公司 2022-07-12 — — CN claimed
WO-2021113282-A1 PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE FMC CORPORATION (US) 2021-06-10 — — WO claimed
WO-2021113284-A1 PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL FMC CORPORATION (US) 2021-06-10 — — WO claimed
CN-111574510-A Pyrimidinyloxybenzene derivatives as herbicides FMC 公司 2020-08-25 — — CN claimed
CN-105916849-B Pyrimidinyloxybenzene derivatives as herbicides FMC公司 2020-07-07 — — CN claimed
US-10654840-B2 Pyrimidinyloxy benzene derivatives as herbicides FMC CORPORATION (US) 2020-05-19 — — US claimed
EP-3094631-B1 PYRIMIDINYLOXY BENZENE DERIVATIVES AS HERBICIDES FMC CORP (US) 2019-01-09 — — EP claimed
EP-4069680-B1 PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL FMC CORP (US) 2026-03-25 — — EP disclosed
US-12516045-B2 Process for synthesis of a 2-thioalkyl pyrimidine FMC CORPORATION (US) 2026-01-06 — — US disclosed
CN-114746406-A Method for synthesizing 2- (5-isoxazolyl) -phenol FMC公司 2022-07-12 — — CN disclosed
WO-2021113284-A1 PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL FMC CORPORATION (US) 2021-06-10 — — WO disclosed
WO-2021113282-A1 PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE FMC CORPORATION (US) 2021-06-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10654840-B2 Pyrimidinyloxy benzene derivatives as herbicides DDT, NQO2, CBR3 KMT2A 2552/4885HPGD 734/4885KDM4E 2150/4885
US-20230068064-A1 PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE DHFR, RTF2, RRM2 KMT2A 1924/4885HPGD 2933/4885KDM4E 2769/4885
US-11447476-B2 Pyrimidinyloxy benzene derivatives as herbicides DDT, NQO2, CBR3 KMT2A 2552/4885HPGD 734/4885KDM4E 2150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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