Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20608683 | 1.00 | SIRT2 (0.39) | SIRT2SIRT1PIN1CTSSCTSK | |
| SCHEMBL22188680 | 0.92 | SIRT2 (0.40) | SIRT2SIRT1PIN1CTSSCTSK | |
| SCHEMBL22188681 | 0.92 | SIRT2 (0.40) | SIRT2SIRT1PIN1CTSSCTSK | |
| SCHEMBL20608714 | 0.92 | SIRT2 (0.36) | SIRT2SIRT1FOLH1PTPN2PTPN1 | |
| SCHEMBL18230531 | 0.92 | SIRT2 (0.36) | SIRT2SIRT1FOLH1PTPN2PTPN1 | |
| SCHEMBL20608668 | 0.91 | SIRT2 (0.40) | SIRT2SIRT1CTSSCTSKFOLH1 | |
| SCHEMBL20608666 | 0.91 | SIRT2 (0.40) | SIRT2SIRT1CTSSCTSKFOLH1 | |
| SCHEMBL20608734 | 0.91 | SIRT2 (0.45) | SIRT2SIRT1FPR2PTPN2PTPN1 | |
| SCHEMBL20608731 | 0.91 | SIRT2 (0.45) | SIRT2SIRT1FPR2PTPN2PTPN1 | |
| SCHEMBL20608689 | 0.90 | TGM2 (0.42) | SIRT2SIRT1PIN1FPR2PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200216401-A1 | NOVEL SYRINGOLIN ANALOGUES AND METHODS OF MAKING AND USING SAME | UNIV BROWN (US) | 2020-07-09 | — | — | US | disclosed |
| US-10597368-B2 | Syringolin analogues and methods of making and using same | BROWN UNIVERSITY (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190010133-A1 | Novel Syringolin Analogues and Methods of Making and Using Same | BROWN UNIVERSITY | 2019-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597368-B2 | Syringolin analogues and methods of making and using same | XIAP, PSMG3, UBQLN1 | SIRT2 1657/4885SIRT1 1801/4885PIN1 971/4885 |
| US-20190010133-A1 | Novel Syringolin Analogues and Methods of Making and Using Same | XIAP, PSMG3, SYVN1 | SIRT2 1684/4885SIRT1 1862/4885PIN1 1126/4885 |
| US-20200216401-A1 | NOVEL SYRINGOLIN ANALOGUES AND METHODS OF MAKING AND USING SAME | XIAP, PSMG3, SYVN1 | SIRT2 1713/4885SIRT1 1878/4885PIN1 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.