Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1818730 | 0.90 | SORT1 (0.67) | SORT1NPC1RAB9AMITFKMT2A | |
| SCHEMBL30417260 | 0.90 | SORT1 (0.67) | SORT1NPC1RAB9AMITFKMT2A | |
| SCHEMBL27486980 | 0.84 | MEN1 (0.63) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL30417052 | 0.84 | MEN1 (0.63) | NPC1RAB9AKMT2AMEN1KDM4E | |
| Hydrochloric Acid SCHEMBL30416887 | 0.82 | MEN1 (0.61) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL30416559 | 0.81 | DEGS1 (0.55) | SORT1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL20610198 | 0.81 | DEGS1 (0.55) | SORT1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL15063477 | 0.81 | SORT1 (0.61) | SORT1NPC1RAB9AMITFKMT2A | |
| SCHEMBL24320131 | 0.80 | SORT1 (0.71) | SORT1NPC1RAB9AMITFKMT2A | |
| SCHEMBL20610060 | 0.80 | SORT1 (0.71) | SORT1NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110869350-B | Alkynyl compounds, their preparation and their therapeutic use | 赛诺菲 | 2023-05-02 | — | — | CN | disclosed |
| US-11078160-B2 | Ethynyl compounds, their preparation and their therapeutic use for the treatment of malaria | SANOFI (FR) | 2021-08-03 | — | — | US | disclosed |
| US-20200281909-A1 | ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE FOR THE TREATMENT OF MALARIA | SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT (FR) | 2020-09-10 | — | — | US | disclosed |
| EP-3649109-A1 | ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE FOR THE TREATMENT OF MALARIA | Sanofi (FR) | 2020-05-13 | — | — | EP | disclosed |
| CN-110869350-A | Alkynyl compounds, their preparation and their therapeutic use | 赛诺菲 | 2020-03-06 | — | — | CN | disclosed |
| WO-2019008027-A1 | ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE FOR THE TREATMENT OF MALARIA | SANOFI (FR) | 2019-01-10 | — | — | WO | disclosed |
| WO-2019008027-A1 | ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE FOR THE TREATMENT OF MALARIA | SANOFI (FR) | 2019-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078160-B2 | Ethynyl compounds, their preparation and their therapeutic use for the treatment of malaria | CYP11B2, CYP11B1, RHOT2 | SORT1 4065/4885NPC1 300/4885RAB9A 733/4885 |
| US-20200281909-A1 | ETHYNYL COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE FOR THE TREATMENT OF MALARIA | CYP11B2, CYP11B1, RHOT2 | SORT1 4065/4885NPC1 300/4885RAB9A 733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.