Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5077759 | 0.88 | ALDH1A1 (0.44) | ALDH1A1ATMHCAR2TSHRHPGD | |
| SCHEMBL547235 | 0.86 | ALDH1A1 (0.48) | ALDH1A1ATMHCAR2TSHRHPGD | |
| SCHEMBL27788160 | 0.81 | ALDH1A1 (0.38) | ALDH1A1ATMHCAR2TSHRHPGD | |
| SCHEMBL11260401 | 0.79 | ALDH1A1 (0.39) | ALDH1A1ATMHCAR2TSHRHPGD | |
| SCHEMBL7383760 | 0.76 | TSHR (0.46) | ALDH1A1ATMHCAR2TSHRHPGD | |
| SCHEMBL6661517 | 0.76 | CA12 (0.42) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL8084070 | 0.76 | ALDH1A1 (0.45) | ALDH1A1ATMHCAR2TSHRHPGD | |
| SCHEMBL7720624 | 0.75 | MAPK1 (0.39) | ALDH1A1TSHRHPGDMAPK1BLM | |
| SCHEMBL8909554 | 0.75 | ALDH1A1 (0.52) | ALDH1A1ATMHCAR2TSHRHPGD | |
| SCHEMBL65775 | 0.75 | ALDH1A1 (0.52) | ALDH1A1ATMHCAR2TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649106-A1 | N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2020-05-13 | — | — | EP | disclosed |
| WO-2019008506-A1 | N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-10 | — | — | WO | disclosed |