SCHEMBL2061071

SCHEMBL2061071

CNC(=O)c1ccccc1NC

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.62
KDM4E B2RXH2 1/20 0.62
ATM Q13315 1/20 0.62
GAA P10253 1/20 0.59
PLK1 P53350 2/20 0.55
ADRA1D P25100 1/20 0.53
ADRA1A P35348 1/20 0.53
ADRA1B P35368 1/20 0.53
ALDH1A1 P00352 2/20 0.48
RECQL P46063 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
CXCR2 P25025 1/20 0.46
KCNA3 P22001 1/20 0.46
CRBN Q96SW2 1/20 0.46
MAPK10 P53779 1/20 0.45
KMT2A Q03164 1/20 0.44
ULK1 O75385 1/20 0.44
BRD4 O60885 1/20 0.43
USP2 O75604 1/20 0.43
PTK2 Q05397 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19552555 0.85 GAA (0.57) POLBKDM4EATMGAAPLK1
SCHEMBL2344909 0.84 GAA (0.71) POLBGAAPLK1ALDH1A1RECQL
SCHEMBL960781 0.83 KDM4E (0.58) POLBKDM4EATMGAAADRA1D
SCHEMBL8628627 0.82 POLB (0.67) POLBKDM4EATMGAAALDH1A1
SCHEMBL21318305 0.82 POLB (0.56) POLBKDM4EATMGAAALDH1A1
SCHEMBL3478287 0.80 ADRA1D (0.56) POLBKDM4EATMGAAADRA1D
SCHEMBL11393249 0.80 KDM4E (0.55) POLBKDM4EATMGAAADRA1D
SCHEMBL21454987 0.80 GAA (0.52) POLBKDM4EATMGAAPLK1
SCHEMBL9189162 0.80 MEN1 (0.64) POLBKDM4EATMALDH1A1RECQL
SCHEMBL13761443 0.80 KDM4E (0.59) POLBKDM4EATMADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3553064-B1 COMPOUND CONTAINING TRICYCLIC HETEROARYL GROUP HANGZHOU INNOGATE PHARMA CO LTD (CN) 2023-06-07 EP disclosed
US-20210252004-A1 USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY WEX MEDICAL LIMITED (HK) 2021-08-19 US disclosed
US-10624896-B2 Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy WEX MEDICAL LIMITED (HK) 2020-04-21 US disclosed
EP-3553064-A1 COMPOUND CONTAINING TRICYCLIC HETEROARYL GROUP Hangzhou Innogate Pharma Co., Ltd. (CN) 2019-10-16 EP disclosed
US-20190160074-A1 USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY WEX MEDICAL LIMITED (HK) 2019-05-30 US disclosed
WO-2019002074-A1 THIAZOLE COMPOUNDS USEFUL AS PRMT5 INHIBITORS BAYER AKTIENGESELLSCHAFT (DE) 2019-01-03 WO disclosed
US-20170144984-A1 MODULATORS OF THE RELAXIN RECEPTOR 1 THE UNITED STATES OF AMERICA AS REPRESENTED BY SECRETARY DEPT OF HEALTH AND HUMAN SERVICE (US) 2017-05-25 US disclosed
EP-2684874-B1 Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors CEPHALON INC (US) 2017-05-17 EP disclosed
US-20170000797-A1 USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY WEX MEDICAL LIMITED (HK) 2017-01-05 US disclosed
US-20170000797-A1 USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY WEX MEDICAL LIMITED (HK) 2017-01-05 US disclosed
US-7241769-B2 Pyrimidines as PLK inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-07-10 US disclosed
EP-1036075-B1 SUBSTITUTED THIAZOLIDINEDIONE AND OXAZOLIDINEDIONE HAVING ANTIDIABETIC, HYPOLIPIDEMIA AND ANTIHYPERTENSIVE PROPERTIES REDDYS LAB LTD DR (IN) 2004-06-23 EP disclosed
US-6664411-B2 Beta-aryl/alpha-oxysubstituted alkylcarboxylic acids of 4-oxo-or thiocarbonylchromenes or thiochromenes; antiobesity, -cholesterol - diabetic agents; agonists of peroxisome proliferator activated receptors; kidney disorders DR. REDDY'S LABORATORIES LIMITED (IN) 2003-12-16 US disclosed
US-6313113-B1 AZOLIDINEDIONE DERIVATIVES, ANALOGUES, TAUTOMERIC FORMS, STEREOISOMERS, POLYMORPHS, SALTS AND SOLVATES; TREATING NON-INSULIN-DEPENDENT DIABETES MELLITUS REDDY-CHEMINOR, INC. 2001-11-06 US disclosed
US-20010027198-A1 Novel heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them DR. REDDY'S RESEARCH FOUNDATION & REDDY-CHEMINOR INC. 2001-10-04 US disclosed
EP-1124807-A1 NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 2001-08-22 EP disclosed
EP-1036075-A1 SUBSTITUTED THIAZOLIDINEDIONE AND OXAZOLIDINEDIONE HAVING ANTIDIABETIC, HYPOLIPIDEMIA AND ANTIHYPERTENSIVE PROPERTIES DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-09-20 EP disclosed
US-6030973-A TYPE II DIABETES (NON-INSULIN-DEPENDENT-DIABETES MELLITUS) POTENTIATION; EFFICIENCY; SIDE EFFECT REDUCTION DR. REDDY'S RESEARCH FOUNDATION (IN) 2000-02-29 US disclosed
WO-1999016758-A1 NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S RESEARCH FOUNDATION (IN) 1999-04-08 WO disclosed
WO-1998045291-A1 SUBSTITUTED THIAZOLIDINEDIONE AND OXAZOLIDINEDIONE HAVING ANTIDIABETIC, HYPOLIPIDEMIA AND ANTIHYPERTENSIVE PROPERTIES DR. REDDY'S RESEARCH FOUNDATION (IN) 1998-10-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10624896-B2 Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy SCN10A, SCN5A, SCN3A POLB 4001/4885KDM4E 2996/4885ATM 3800/4885
US-20170000797-A1 USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY SCN10A, SCN3A, SCN1A POLB 3303/4885KDM4E 3623/4885ATM 3398/4885
US-20210252004-A1 USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY SCN10A, SCN5A, SCN3A POLB 4001/4885KDM4E 2996/4885ATM 3800/4885
US-20010027198-A1 Novel heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them CYP11B1, CYP46A1, CYP51A1 POLB 2887/4885KDM4E 2843/4885ATM 4435/4885
US-20170144984-A1 MODULATORS OF THE RELAXIN RECEPTOR 1 RXFP1, RXFP2, RXFP3 POLB 4687/4885KDM4E 4395/4885ATM 2761/4885
US-20190160074-A1 USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY SCN10A, SCN5A, SCN3A POLB 4001/4885KDM4E 2996/4885ATM 3800/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.