Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.68 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.50 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329940 | 0.88 | F2RL1 (0.85) | F2RL1FFAR1POLBALOX5ALDH1A1 | |
| SCHEMBL20221726 | 0.87 | F2RL1 (0.52) | F2RL1FFAR1POLBALOX5ALDH1A1 | |
| SCHEMBL20221724 | 0.85 | F2RL1 (0.70) | F2RL1FFAR1POLBALOX5ALDH1A1 | |
| SCHEMBL20610768 | 0.85 | F2RL1 (0.70) | F2RL1FFAR1POLBALOX5ALDH1A1 | |
| SCHEMBL7371103 | 0.85 | HTT (0.53) | F2RL1FFAR1POLBALOX5ALDH1A1 | |
| SCHEMBL9096140 | 0.85 | F2RL1 (0.74) | F2RL1FFAR1POLBALOX5ALDH1A1 | |
| SCHEMBL20610759 | 0.84 | F2RL1 (0.68) | F2RL1FFAR1POLBALOX5ALDH1A1 | |
| SCHEMBL9664592 | 0.83 | F2RL1 (0.66) | F2RL1FFAR1POLBALOX5ALDH1A1 | |
| SCHEMBL8585437 | 0.83 | F2RL1 (0.66) | F2RL1POLBALOX5 | |
| SCHEMBL24800806 | 0.81 | F2RL1 (0.74) | F2RL1FFAR1ALOX5ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118515685-A | Synthesis of halichondrin | 哈佛大学的校长及成员们 | 2024-08-20 | — | — | CN | disclosed |
| US-20230339959-A1 | PHARMACEUTICALLY EFFECTIVE COMPOUNDS INHIBITING SELECTIVELY THE MYOSIN 2 ISOFORMS | EÖTVÖS LORÁND TUDOMÁNYEGYETEM (HU) | 2023-10-26 | — | — | US | disclosed |
| US-20230135188-A1 | FE/CU-MEDIATED KETONE SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230135188-A1 | FE/CU-MEDIATED KETONE SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230128195-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230128195-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230128195-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
| EP-4169924-A2 | SYNTHESIS OF HALICHONDRINS | President And Fellows Of Harvard College (US) | 2023-04-26 | — | — | EP | disclosed |
| US-11548898-B2 | Synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-01-10 | — | — | US | disclosed |
| US-11548898-B2 | Synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-01-10 | — | — | US | disclosed |
| EP-3649135-B1 | SYNTHESIS OF HALICHONDRINS | HARVARD COLLEGE (US) | 2022-12-28 | — | — | EP | disclosed |
| EP-3649135-B1 | SYNTHESIS OF HALICHONDRINS | HARVARD COLLEGE (US) | 2022-12-28 | — | — | EP | disclosed |
| US-20210230177-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-07-29 | — | — | US | disclosed |
| US-20210230177-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-07-29 | — | — | US | disclosed |
| US-20210179522-A9 | FE/CU-MEDIATED KETONE SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-06-17 | — | — | US | disclosed |
| CN-111433211-A | Synthesis of halichondrin | 哈佛大学的校长及成员们 | 2020-07-17 | — | — | CN | disclosed |
| US-20200165183-A1 | FE/CU-MEDIATED KETONE SYNTHESIS | President and Fellows of Flarvard College (US) | 2020-05-28 | — | — | US | disclosed |
| EP-3649135-A1 | SYNTHESIS OF HALICHONDRINS | President and Fellows of Harvard College (US) | 2020-05-13 | — | — | EP | disclosed |
| WO-2019009956-A1 | FE/CU-MEDIATED KETONE SYNTHESIS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-01-10 | — | — | WO | disclosed |
| WO-2019010363-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179522-A9 | FE/CU-MEDIATED KETONE SYNTHESIS | TKT, COASY, FECH | F2RL1 4391/4885FFAR1 3087/4885POLB 2509/4885 |
| US-20200165183-A1 | FE/CU-MEDIATED KETONE SYNTHESIS | TKT, COASY, FECH | F2RL1 4391/4885FFAR1 3087/4885POLB 2509/4885 |
| US-20230135188-A1 | FE/CU-MEDIATED KETONE SYNTHESIS | TKT, COASY, FECH | F2RL1 4391/4885FFAR1 3087/4885POLB 2509/4885 |
| US-11548898-B2 | Synthesis of halichondrins | H1-3, NISCH, H1-5 | F2RL1 4323/4885FFAR1 4379/4885POLB 1648/4885 |
| US-20230339959-A1 | PHARMACEUTICALLY EFFECTIVE COMPOUNDS INHIBITING SELECTIVELY THE MYOSIN 2 ISOFORMS | MYH2, MYLK2, MYO1B | F2RL1 1908/4885FFAR1 4727/4885POLB 1490/4885 |
| US-20230128195-A1 | SYNTHESIS OF HALICHONDRINS | H1-3, NISCH, HDAC11 | F2RL1 4305/4885FFAR1 4398/4885POLB 1606/4885 |
| US-20210230177-A1 | SYNTHESIS OF HALICHONDRINS | H1-3, NISCH, HDAC11 | F2RL1 4314/4885FFAR1 4372/4885POLB 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.