Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLK1 | O15075 | 7/20 | 0.38 |
| ▸ | MAPK7 | Q13164 | 6/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | PIK3C2G | O75747 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.35 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21938134 | 0.74 | DCLK1 (0.68) | DCLK1MAPK7LRRK2PIK3CDAURKA | |
| SCHEMBL24742746 | 0.74 | NUAK1 (0.59) | MAPK7LRRK2PIK3CDAURKAPIK3C2G | |
| SCHEMBL20628525 | 0.73 | AURKA (0.69) | DCLK1MAPK7LRRK2PIK3CDAURKA | |
| SCHEMBL24334888 | 0.71 | CASP3 (0.38) | DCLK1MAPK7LRRK2PIK3CDAURKA | |
| SCHEMBL21938547 | 0.71 | PIK3CD (0.70) | DCLK1MAPK7LRRK2PIK3CDAURKA | |
| SCHEMBL616737 | 0.69 | LRRK2 (0.73) | DCLK1MAPK7LRRK2TNK2GAK | |
| SCHEMBL22663689 | 0.69 | NUAK1 (0.45) | DCLK1MAPK7LRRK2PIK3CDAURKA | |
| SCHEMBL29583687 | 0.66 | CASP3 (0.40) | MAPK7KDRTNK2BRD4 | |
| SCHEMBL16980134 | 0.64 | POLB (0.39) | AURKAAURKBKDR | |
| SCHEMBL11486350 | 0.63 | ALDH1A1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424929-A1 | PYRIMIDINE SEVEN-MEMBERED-RING COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF | Anhui New Star Pharmaceutical Development Co., Ltd (CN) | 2019-01-09 | — | — | EP | disclosed |