Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 7/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.41 |
| ▸ | MIF | P14174 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20628752 | 0.86 | MAPT (0.41) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL18031760 | 0.86 | ESR1 (0.44) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL7033347 | 0.82 | MAOB (0.43) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL21294262 | 0.74 | THRB (0.46) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL17085449 | 0.70 | ALDH1A1 (0.49) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL21294303 | 0.69 | MAPT (0.40) | MAPTRAB9AESR1ESR2KMT2A | |
| SCHEMBL30574498 | 0.69 | MAPT (0.40) | MAPTRAB9AESR1ESR2KMT2A | |
| SCHEMBL2324085 | 0.68 | MIF (0.47) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL2327566 | 0.68 | MIF (0.47) | ALDH1A1MAPTRAB9AESR1ESR2 | |
| SCHEMBL7224651 | 0.68 | ESR1 (0.51) | ALDH1A1MAPTESR1ESR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3059231-B1 | CHROMENE DERIVATIVES AS INHIBITORS OF TCR-NCK INTERACTION | ARTAX BIOPHARMA INC (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3059232-B1 | CHROMENE DERIVATIVES SUBSTITUTED BY ALKOXIDE AS INHIBITORS OF THE TCR-NCK INTERACTION | ARTAX BIOPHARMA INC (US) | 2019-01-09 | — | — | EP | disclosed |