Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20629314 | 0.82 | ALDH1A1 (0.49) | MAOBKMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL7224651 | 0.80 | ESR1 (0.51) | MAOBKMT2ATHRBALDH1A1MAPT | |
| SCHEMBL7232088 | 0.77 | PAM (0.43) | MAOBKMT2ATHRBALDH1A1KDM4E | |
| SCHEMBL9376747 | 0.76 | MAOB (0.44) | MAOBKMT2APKMTSHRALDH1A1 | |
| SCHEMBL9370825 | 0.76 | MAOB (0.41) | MAOBKMT2APKMTSHRALDH1A1 | |
| SCHEMBL7030875 | 0.76 | MAOB (0.41) | MAOBKMT2APKMTSHRALDH1A1 | |
| SCHEMBL3607151 | 0.74 | ESR1 (0.41) | KMT2APKMALDH1A1MAPTHTT | |
| SCHEMBL3607145 | 0.74 | ESR1 (0.41) | KMT2APKMALDH1A1MAPTHTT | |
| SCHEMBL16139564 | 0.72 | CES1 (0.44) | MAOBPKMALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL21294262 | 0.72 | THRB (0.46) | KMT2ATHRBPKMALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107454902-B | Chromene derivatives as phosphoinositide 3-kinase inhibitors | 奇斯药制品公司 | 2020-09-15 | — | — | CN | disclosed |
| EP-3283481-B1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-03-13 | — | — | EP | disclosed |
| EP-3283481-B1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARM SPA (IT) | 2019-03-13 | — | — | EP | disclosed |
| US-9968604-B2 | Chromene derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-05-15 | — | — | US | disclosed |
| US-9968604-B2 | Chromene derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-05-15 | — | — | US | disclosed |
| US-9968604-B2 | Chromene derivatives as phoshoinositide 3-kinases inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-05-15 | — | — | US | disclosed |
| EP-3283481-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2018-02-21 | — | — | EP | disclosed |
| US-20160303123-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | US | disclosed |
| WO-2016166239-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | WO | disclosed |
| US-20160303123-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | US | disclosed |
| WO-2016166239-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-10-20 | — | — | WO | disclosed |
| US-6596758-B1 | Treatment of dislipidaemias, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to processes allowing the preparation of these compounds. | MERCK PATENT GMBH (DE) | 2003-07-22 | — | — | US | disclosed |
| EP-1140893-B1 | BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-05 | — | — | EP | disclosed |
| US-6509362-B2 | Cholesteryl acyl transferase (ACAT) inhibitors; treatment of hyperlipidaemia and atherosclerosis. | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2003-01-21 | — | — | US | disclosed |
| US-20020068739-A1 | New N-phenylamide and N-pyridylamide derivatives, method of preparing them and pharmaceutical compositions containing them | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-06-06 | — | — | US | disclosed |
| US-6339097-B1 | FOR THERAPY OF HYPERLIPIDAEMIA AND ATHEROSCLEROSIS; CHOLESTERYL ACYL TRANSFERASE (ACAT) INHIBITORS | MERCK PATENT GMBH (DE) | 2002-01-15 | — | — | US | disclosed |
| EP-1140893-A1 | BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| EP-1040109-A1 | N-PHENYLAMIDE AND N-PYRIDYLAMIDE DERIVATIVES, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK PATENT GmbH (DE) | 2000-10-04 | — | — | EP | disclosed |
| WO-2000039113-A1 | BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2000-07-06 | — | — | WO | disclosed |
| WO-1999033825-A1 | N-PHENYLAMIDE AND N-PYRIDYLAMIDE DERIVATIVES, METHOD OF PREPARING THEM AND PHARMACEUTICAL COMPOSITONS CONTAINING THEM | MERCK PATENT GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068739-A1 | New N-phenylamide and N-pyridylamide derivatives, method of preparing them and pharmaceutical compositions containing them | ACAT2, LCAT, ACAT1 | MAOB 293/4885KMT2A 884/4885THRB 3341/4885 |
| US-20160303123-A1 | CHROMENE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS | PIKFYVE, PI4KA, PIP4K2B | MAOB 3153/4885KMT2A 4009/4885THRB 2047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.