Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542148 | 0.83 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1MAPTLMNAHTT | |
| SCHEMBL4687389 | 0.76 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPTLMNAHTT | |
| SCHEMBL1540042 | 0.72 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPTLMNAHTT | |
| SCHEMBL1540043 | 0.69 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPTLMNAHTT | |
| SCHEMBL4687384 | 0.69 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1MAPTLMNAHTT | |
| SCHEMBL4789499 | 0.68 | SMN1; SMN2 (0.50) | ALDH1A1L3MBTL1MAPTHTTNPC1 | |
| SCHEMBL692444 | 0.68 | L3MBTL1 (0.58) | ALDH1A1L3MBTL1NPC1RAB9AHSD17B10 | |
| SCHEMBL20630419 | 0.66 | — | — | |
| SCHEMBL1537973 | 0.66 | — | — | |
| SCHEMBL23516950 | 0.66 | NPC1 (0.45) | ALDH1A1L3MBTL1MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424931-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES THAT INHIBIT MCL-1 PROTEIN | AMGEN INC (US) | 2020-02-12 | — | — | EP | disclosed |
| EP-3424931-A2 | TETRAHYDRONAPHTHALENE DERIVATIVES THAT INHIBIT MCL-1 PROTEIN | Amgen, Inc (US) | 2019-01-09 | — | — | EP | disclosed |