Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 11/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27858187 | 0.83 | MAPT (0.44) | ALDH1A1TDP1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL27680977 | 0.82 | MEN1 (0.45) | ALDH1A1TDP1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL31443866 | 0.81 | CHEK1 (0.33) | CHEK1ALDH1A1TDP1LMNAPDE4A | |
| SCHEMBL11224598 | 0.81 | CHEK1 (0.61) | CHEK1ALDH1A1TDP1LMNASIRT6 | |
| SCHEMBL10724484 | 0.79 | CHEK1 (0.48) | CHEK1ALDH1A1TDP1LMNASIRT6 | |
| SCHEMBL2389958 | 0.78 | PDE4A (0.61) | ALDH1A1TDP1LMNAPDE4APDE4B | |
| SCHEMBL30395745 | 0.77 | CHEK1 (0.52) | CHEK1ALDH1A1TDP1LMNASIRT6 | |
| SCHEMBL26087669 | 0.77 | CHEK1 (0.52) | CHEK1ALDH1A1TDP1LMNASIRT6 | |
| SCHEMBL29033980 | 0.77 | MAPT (0.52) | ALDH1A1TDP1MAPTL3MBTL1MEN1 | |
| SCHEMBL29033968 | 0.77 | MAPT (0.41) | ALDH1A1TDP1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649127-B1 | SUBSTITUTED AZAINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-09-08 | — | — | EP | disclosed |
| WO-2019008011-A1 | NEW SUBSTITUTED AZAINDOLINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-10 | — | — | WO | disclosed |