Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 12/20 | 0.76 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | USP14 | P54578 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21882376 | 0.88 | ATF4 (0.57) | ATF4ALDH1A1KCNA3 | |
| SCHEMBL21819632 | 0.86 | ATF4 (1.00) | ATF4ALDH1A1 | |
| SCHEMBL21882036 | 0.86 | ATF4 (0.78) | ATF4 | |
| SCHEMBL23920294 | 0.85 | ATF4 (0.60) | ATF4ALDH1A1 | |
| SCHEMBL19705177 | 0.85 | ATF4 (0.71) | ATF4SSTR4ALDH1A1USP14 | |
| SCHEMBL21819687 | 0.84 | ATF4 (0.86) | ATF4ALDH1A1 | |
| SCHEMBL28593095 | 0.83 | ATF4 (0.57) | ATF4ALDH1A1 | |
| SCHEMBL20632012 | 0.82 | ATF4 (0.64) | ATF4ALDH1A1 | |
| SCHEMBL29988199 | 0.81 | ATF4 (0.59) | ATF4SSTR4ALDH1A1 | |
| SCHEMBL4030683 | 0.81 | ATF4 (0.71) | ATF4SSTR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220071966-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2022-03-10 | — | — | US | disclosed |
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| CN-112912082-A | Integrated stress pathway inhibitors | 普拉西斯生物技术有限责任公司 | 2021-06-04 | — | — | CN | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | ATF4 1/4885SSTR4 1198/4885ALDH1A1 4073/4885 |
| US-20220071966-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885SSTR4 1198/4885ALDH1A1 4073/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885SSTR4 1198/4885ALDH1A1 4073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.