Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632107 | 0.83 | TLR8 (0.35) | TLR8HDAC4MEF2D | |
| SCHEMBL20632765 | 0.83 | TLR8 (0.34) | TLR8 | |
| SCHEMBL20632115 | 0.83 | TLR8 (0.38) | TLR8HDAC4MEF2D | |
| SCHEMBL20632264 | 0.81 | TLR8 (0.40) | TLR8HDAC4MEF2D | |
| SCHEMBL20631622 | 0.80 | MEN1 (0.36) | TLR8HDAC4MEF2D | |
| SCHEMBL20632097 | 0.80 | MPL (0.35) | TLR8 | |
| SCHEMBL20632508 | 0.80 | NPSR1 (0.35) | TLR8 | |
| SCHEMBL20633090 | 0.80 | TLR8 (0.35) | TLR8HDAC4 | |
| SCHEMBL20632633 | 0.80 | TLR8 (0.34) | TLR8HDAC4MEF2D | |
| SCHEMBL20632322 | 0.79 | ALOX15 (0.41) | TLR8SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |