Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 2/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632322 | 0.94 | ALOX15 (0.41) | NPSR1ALOX15TSHRCASP1HSD17B10 | |
| SCHEMBL20632097 | 0.89 | MPL (0.35) | TLR8 | |
| SCHEMBL20632467 | 0.87 | XBP1 (0.30) | NPSR1MITFNOD1XBP1NPC1 | |
| SCHEMBL20632945 | 0.86 | NPSR1 (0.32) | NPSR1ALOX15TSHRCASP1HSD17B10 | |
| SCHEMBL20631544 | 0.84 | WNT3A (0.37) | ABL1PDGFRBSRCPDGFRAPRKCA | |
| SCHEMBL20632765 | 0.82 | TLR8 (0.34) | TLR8 | |
| SCHEMBL20632399 | 0.82 | TLR8 (0.41) | TLR8PIK3CDPIK3CAPIK3CG | |
| SCHEMBL20631655 | 0.81 | CHRNB2 (0.32) | NPSR1ABL1PDGFRBSRCPDGFRA | |
| SCHEMBL20632126 | 0.80 | TLR8 (0.34) | TLR8 | |
| SCHEMBL20632360 | 0.80 | USP7 (0.33) | ABL1PIK3CGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |