Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11909828 | 0.79 | MAP2K3 (0.46) | ABL1MAP4K1 | |
| SCHEMBL16835968 | 0.74 | CYP1A2 (0.46) | ABL1CYP11B1CYP11B2CYP1A2CYP2E1 | |
| SCHEMBL22808268 | 0.73 | CDK2 (0.58) | ABL1CYP11B1CYP11B2CYP1A2CYP2E1 | |
| SCHEMBL16835877 | 0.72 | CYP2A6 (0.57) | ABL1CYP1A2CYP3A4CYP2A6CYP2C19 | |
| SCHEMBL11241124 | 0.72 | ROCK2 (0.43) | ABL1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29988790 | 0.72 | TDO2 (0.49) | ABL1CYP11B1CYP11B2CYP1A2CYP2E1 | |
| SCHEMBL3421743 | 0.72 | TDO2 (0.49) | ABL1CYP11B1CYP11B2CYP1A2CYP2E1 | |
| SCHEMBL30309922 | 0.72 | LCK (0.46) | ABL1CYP11B1CYP11B2CYP1A2CYP2E1 | |
| SCHEMBL15784053 | 0.72 | LCK (0.46) | ABL1CYP11B1CYP11B2CYP1A2CYP2E1 | |
| SCHEMBL24667225 | 0.71 | CYP2A6 (0.56) | CYP11B1CYP11B2CYP1A2CYP2A6PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |