Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631481 | 0.90 | GAA (0.38) | KDM4EPRKD1EGFRPIM1PDE10A | |
| SCHEMBL20633048 | 0.90 | PRMT5 (0.39) | HDAC8HCRTR1HCRTR2EGFRGSK3B | |
| SCHEMBL20632764 | 0.90 | GSK3B (0.36) | PRKD1GSK3BDYRK1A | |
| SCHEMBL16776273 | 0.90 | FAAH (0.36) | HDAC8HCRTR1HCRTR2KDM4ENPC1 | |
| SCHEMBL20633316 | 0.89 | OPRK1 (0.35) | HDAC8HCRTR1HCRTR2EGFRGSK3B | |
| SCHEMBL20632516 | 0.86 | PRMT5 (0.36) | DYRK1A | |
| SCHEMBL20631680 | 0.86 | GAA (0.38) | EGFRPIM1NPC1RAB9AGAA | |
| SCHEMBL20633061 | 0.84 | GSK3B (0.33) | HDAC8HCRTR1HCRTR2KDM4ENPC1 | |
| SCHEMBL17778903 | 0.84 | FAAH (0.35) | HDAC8HCRTR1HCRTR2KDM4EPIM1 | |
| SCHEMBL16754331 | 0.84 | FAAH (0.35) | HDAC8HCRTR1HCRTR2KDM4EPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |