Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 6/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632172 | 0.90 | ROCK2 (0.33) | HCRTR2EGFRGSK3BCHRM4FAAH | |
| SCHEMBL20633048 | 0.90 | PRMT5 (0.39) | HDAC8HCRTR1HCRTR2PRMT5WDR77 | |
| SCHEMBL20632281 | 0.90 | CHRM4 (0.35) | GSK3BDYRK1ACHRM4AKT1 | |
| SCHEMBL16776289 | 0.90 | FAAH (0.35) | OPRK1HDAC8HCRTR1HCRTR2PRMT5 | |
| SCHEMBL20631665 | 0.90 | SLC9A1 (0.35) | OPRK1HCRTR1HCRTR2EGFRFAAH | |
| SCHEMBL20632297 | 0.89 | HDAC8 (0.34) | HDAC8HCRTR1HCRTR2EGFRGSK3B | |
| SCHEMBL20632516 | 0.86 | PRMT5 (0.36) | PRMT5WDR77DYRK1A | |
| SCHEMBL20633332 | 0.85 | SLC9A1 (0.35) | OPRK1EGFRFAAHMTOR | |
| SCHEMBL20631680 | 0.83 | GAA (0.38) | PRMT5WDR77EGFR | |
| SCHEMBL20632133 | 0.81 | MPL (0.35) | SCN9AGSK3BFAAHRPS6KB1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |