Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632193 | 0.92 | FYN (0.37) | LMNASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL20633441 | 0.91 | FYN (0.39) | LMNASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL20633162 | 0.90 | AURKA (0.38) | LMNASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL20632995 | 0.89 | GRIN1 (0.31) | — | |
| SCHEMBL20632245 | 0.89 | LRRK2 (0.33) | NTRK1KDM1A | |
| SCHEMBL20632430 | 0.89 | HTR2C (0.40) | SMN1; SMN2NPC1MEN1KMT2AMAPT | |
| SCHEMBL20632265 | 0.89 | BRAF (0.31) | RAF1BRAF | |
| SCHEMBL20632046 | 0.88 | CYP1A2 (0.43) | LMNASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL20632643 | 0.88 | CSF1R (0.38) | LMNASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL20632313 | 0.88 | PHGDH (0.33) | NPC1RAB9ACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |