Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | RHOA | P61586 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20633441 | 0.93 | FYN (0.39) | FYNMEN1KMT2AALDH1A1RAF1 | |
| SCHEMBL20632643 | 0.92 | CSF1R (0.38) | FYNMEN1KMT2AALDH1A1RAF1 | |
| SCHEMBL20633005 | 0.90 | LMNA (0.38) | FYNMEN1KMT2AALDH1A1RAF1 | |
| SCHEMBL20632024 | 0.90 | RHOA (0.47) | FYNRHOAHTTMAPTLMNA | |
| SCHEMBL20633401 | 0.90 | HTR2C (0.42) | AURKAFYNMEN1KMT2ARAF1 | |
| SCHEMBL20632046 | 0.89 | CYP1A2 (0.43) | FYNMEN1KMT2AALDH1A1CSF1R | |
| SCHEMBL20632673 | 0.87 | CA2 (0.36) | FYNALDH1A1RAF1KDM1ACSF1R | |
| SCHEMBL20632193 | 0.85 | FYN (0.37) | FYNMEN1KMT2ARAF1RHOA | |
| SCHEMBL20632070 | 0.85 | BRAF (0.34) | FYNALDH1A1RAF1CSF1RKIT | |
| SCHEMBL20632922 | 0.85 | KDM4E (0.36) | FYNMEN1KMT2AALDH1A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |