Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20633162 | 0.93 | AURKA (0.38) | FYNMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL20632643 | 0.92 | CSF1R (0.38) | FYNMEN1ALDH1A1KMT2ARHOA | |
| SCHEMBL20632046 | 0.92 | CYP1A2 (0.43) | FYNMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL20633005 | 0.91 | LMNA (0.38) | FYNMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL20633401 | 0.91 | HTR2C (0.42) | FYNMAPTMAPK1MEN1KMT2A | |
| SCHEMBL20632024 | 0.89 | RHOA (0.47) | FYNMAPTMAPK1CCKBRRHOA | |
| SCHEMBL20632673 | 0.87 | CA2 (0.36) | FYNMAPTMAPK1ALDH1A1CNR1 | |
| SCHEMBL20632193 | 0.87 | FYN (0.37) | FYNMAPK1MEN1KMT2ARHOA | |
| SCHEMBL20632070 | 0.86 | BRAF (0.34) | FYNMAPTALDH1A1LMNANPC1 | |
| SCHEMBL20632922 | 0.86 | KDM4E (0.36) | FYNMAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |