Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670295 | 0.90 | HTR2C (0.39) | HTR2CHTR2ATRPV1CA9HTR2B | |
| SCHEMBL19365693 | 0.86 | TRPV1 (0.34) | TRPV1PRMT3ROCK2 | |
| SCHEMBL16776157 | 0.84 | ROCK2 (0.36) | TRPV1PRMT3ROCK2CA9 | |
| SCHEMBL20632930 | 0.84 | KMT2A (0.45) | HTR2CHTR2AGAALMNANPSR1 | |
| SCHEMBL20633030 | 0.83 | HTR2C (0.41) | HTR2CHTR2ALMNANPSR1CA9 | |
| SCHEMBL17655361 | 0.81 | ROCK2 (0.36) | HTR2CHTR2ATRPV1PRMT3ROCK2 | |
| SCHEMBL20632604 | 0.80 | FGFR4 (0.45) | GAALMNANPSR1CA9KMO | |
| SCHEMBL20631471 | 0.79 | BCL6 (0.33) | — | |
| SCHEMBL20632940 | 0.79 | TEK (0.33) | ROCK2 | |
| SCHEMBL19365347 | 0.78 | BTK (0.36) | TRPV1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |