Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 6/20 | 0.35 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632618 | 0.98 | CYP11B2 (0.35) | CYP11B2GSK3BDYRK1AKCNH2HRH3 | |
| SCHEMBL20632592 | 0.89 | CYP1A2 (0.38) | CYP11B2DYRK1AKCNH2HRH3CYP11B1 | |
| SCHEMBL20631659 | 0.86 | GRIN1 (0.32) | — | |
| SCHEMBL20631699 | 0.82 | CYP11B2 (0.35) | CYP11B2 | |
| SCHEMBL20632213 | 0.81 | GRIN1 (0.31) | — | |
| SCHEMBL20632289 | 0.81 | CYP1A2 (0.34) | CYP11B2CYP11B1 | |
| SCHEMBL20631589 | 0.81 | PHGDH (0.35) | KCNH2MAPTNTRK1 | |
| SCHEMBL20633408 | 0.80 | CYP11B2 (0.35) | CYP11B2 | |
| SCHEMBL20632750 | 0.80 | GRIN1 (0.37) | — | |
| SCHEMBL20632505 | 0.78 | NPC1 (0.39) | MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |