Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 3/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20632479 | 0.93 | LMNA (0.32) | BRAF | |
| SCHEMBL20631813 | 0.92 | BRAF (0.32) | NPC1RAB9ABRAF | |
| SCHEMBL20632265 | 0.89 | BRAF (0.31) | BRAFRAF1 | |
| SCHEMBL20633005 | 0.89 | LMNA (0.38) | NPC1RAB9ABRAFRAF1 | |
| SCHEMBL20632070 | 0.88 | BRAF (0.34) | NPC1BRAFRAF1 | |
| SCHEMBL20632330 | 0.87 | TLR8 (0.36) | BRAFRAF1 | |
| SCHEMBL20632245 | 0.85 | LRRK2 (0.33) | — | |
| SCHEMBL20632995 | 0.85 | GRIN1 (0.31) | — | |
| SCHEMBL20632193 | 0.84 | FYN (0.37) | NPC1RAB9ABRAFRAF1 | |
| SCHEMBL20632313 | 0.84 | PHGDH (0.33) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |