SCHEMBL20633445

SCHEMBL20633445

CC(=O)c1cc(F)c2nc(N)sc2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
LMNA P02545 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.46
HSD17B10 Q99714 1/20 0.42
NSD1 Q96L73 2/20 0.41
CYP2C19 P33261 1/20 0.40
MEN1 O00255 2/20 0.38
MAPT P10636 2/20 0.38
KMT2A Q03164 2/20 0.38
GAA P10253 2/20 0.38
TNF P01375 1/20 0.38
HPGD P15428 1/20 0.38
HTT P42858 1/20 0.38
MCL1 Q07820 1/20 0.38
NOD2 Q9HC29 1/20 0.38
NOD1 Q9Y239 1/20 0.38
NSD2 O96028 1/20 0.37
NSD3 Q9BZ95 1/20 0.37
RAB9A P51151 2/20 0.36
PKM P14618 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23196210 0.86 ALDH1A1 (0.51) ALDH1A1LMNASMN1; SMN2HSD17B10NSD1
SCHEMBL2275450 0.84 LMNA (0.51) ALDH1A1LMNASMN1; SMN2HSD17B10CYP2C19
SCHEMBL19899989 0.80 ALDH1A1 (0.47) ALDH1A1LMNASMN1; SMN2HSD17B10MEN1
SCHEMBL14044812 0.75 HSD17B10 (0.68) ALDH1A1LMNASMN1; SMN2HSD17B10NSD1
SCHEMBL474219 0.74 ALDH1A1 (0.61) ALDH1A1LMNASMN1; SMN2HSD17B10NSD1
SCHEMBL21289918 0.74 CYP2C19 (0.38) ALDH1A1LMNASMN1; SMN2HSD17B10NSD1
SCHEMBL17859475 0.72 RAB9A (0.40) ALDH1A1LMNASMN1; SMN2HSD17B10MEN1
SCHEMBL2314657 0.71 NSD1 (0.64) ALDH1A1LMNASMN1; SMN2HSD17B10NSD1
SCHEMBL13486488 0.71 ALDH1A1 (0.57) ALDH1A1LMNASMN1; SMN2HSD17B10NSD1
SCHEMBL19939699 0.71 ALDH1A1 (0.53) ALDH1A1LMNASMN1; SMN2HSD17B10NSD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019007418-A1 FXR RECEPTOR AGONIST 山东轩竹医药科技有限公司 2019-01-10 WO disclosed