Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25155623 | 0.83 | KDM4E (0.43) | CFTRSOS1KDM4ECYP1A2CYP2C19 | |
| SCHEMBL31312693 | 0.81 | PTPN5 (0.39) | KDM4ECYP1A2CYP2C19CYP2C9PDK1 | |
| SCHEMBL27214479 | 0.81 | ATR (0.42) | CFTRSOS1KDM4ECYP1A2CYP2C19 | |
| SCHEMBL30264748 | 0.79 | KDM4E (0.49) | CFTRKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL11922634 | 0.76 | CFTR (0.49) | CFTRSOS1KDM4ECYP1A2CYP2C19 | |
| SCHEMBL1173751 | 0.75 | KDM4E (0.54) | KDM4ECYP1A2CYP2C19CYP2C9PDK1 | |
| SCHEMBL979300 | 0.75 | PDK2 (0.53) | KDM4ECYP1A2CYP2C19CYP2C9PDK1 | |
| SCHEMBL17042042 | 0.74 | SOS1 (0.44) | CFTRSOS1KDM4ECYP1A2CYP2C19 | |
| SCHEMBL28439983 | 0.74 | CYP1A2 (0.57) | CFTRKDM4ECYP1A2CYP2C19CYP2C9 | |
| SCHEMBL5058519 | 0.74 | KDM4E (0.55) | CFTRKDM4ECYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109952298-B | Indole carboxamide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| EP-3650448-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2020-05-13 | — | — | EP | disclosed |
| US-20200131123-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-04-30 | — | — | US | disclosed |
| WO-2019007382-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2019-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131123-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | TPH1, TPH2, PAH | CFTR 2557/4885SOS1 1995/4885KDM4E 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.