Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 12/20 | 0.69 |
| ▸ | PRKCI | P41743 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MPI | P34949 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20635613 | 0.93 | PRKCZ (0.68) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL20635749 | 0.86 | PRKCZ (0.87) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL3386676 | 0.82 | PRKCZ (1.00) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL13837694 | 0.82 | PRKCZ (0.69) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL3384989 | 0.77 | PRKCZ (0.74) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL690278 | 0.75 | PRKCZ (0.84) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL8289654 | 0.75 | PRKCZ (1.00) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL1554707 | 0.74 | PRKCZ (0.75) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL8290826 | 0.74 | PRKCZ (0.79) | PRKCZPRKCIALDH1A1HSD17B10HPGD | |
| SCHEMBL21253180 | 0.74 | PRKCZ (0.66) | PRKCZPRKCIALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019008152-A1 | 3-CYANOTHIOPHENE DERIVATIVES AS INHIBITORS OF THE PD-1/PD-L1 PROTEIN/PROTEIN INTERACTION | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2019-01-10 | — | — | WO | disclosed |