SCHEMBL20636714

SCHEMBL20636714

CCSc1c(C(=O)Cl)nn2ccc(C(F)(F)F)cc12

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.36
SLC2A1 P11166 1/20 0.34
MAT2A P31153 4/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
GFER P55789 1/20 0.32
DDR1 Q08345 3/20 0.31
ALDH1A1 P00352 2/20 0.31
KDM4E B2RXH2 1/20 0.31
LMNA P02545 2/20 0.31
RECQL P46063 1/20 0.31
MAPT P10636 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
GRIN2B Q13224 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20636708 0.89 POLB (0.37) HTTSLC2A1MAT2APTGDR2NPC1
SCHEMBL20636705 0.89 KMT2A (0.37) HTTSLC2A1MAT2APTGDR2NPC1
Hydrochloric Acid SCHEMBL20636716 0.88 POLB (0.37) HTTSLC2A1MAT2APTGDR2NPC1
SCHEMBL20636702 0.85 MAPT (0.39) ALDH1A1KDM4EMAPTMEN1KMT2A
SCHEMBL20636712 0.82 MLYCD (0.34) HTTSLC2A1PTGDR2NPC1RAB9A
SCHEMBL20636695 0.72 PDE10A (0.37) MAT2ALMNA
SCHEMBL19711966 0.71 USP7 (0.39) HTTMAT2APTGDR2NPC1RAB9A
SCHEMBL25251710 0.70 POLB (0.39) HTTMAT2APTGDR2NPC1ALDH1A1
SCHEMBL20636710 0.70 POLB (0.39) HTTPTGDR2DDR1KMT2A
SCHEMBL20636720 0.69 MAPT (0.41) ALDH1A1KDM4EMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10759815-B2 Condensed heterocyclic compounds and pesticides NISSAN CHEMICAL CORPORATION (JP) 2020-09-01 US disclosed
US-20200223868-A1 CONDENSED HETEROCLYCLIC COMPOUNDS AND PESTICIDES NISSAN CHEMICAL CORPORATION (JP) 2020-07-16 US disclosed
US-10640518-B2 Condensed heterocyclic compounds and pesticides NISSAN CHEMICAL CORPORATION (JP) 2020-05-05 US disclosed
US-20200095263-A1 CONDENSED HETEROCYCLIC COMPOUNDS AND PESTICIDES NISSAN CHEMICAL CORPORATION (JP) 2020-03-26 US disclosed
US-10544163-B2 Condensed heterocyclic compounds and pesticides NISSAN CHEMICAL CORPORATION (JP) 2020-01-28 US disclosed
EP-3428166-A1 CONDENSED HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT Nissan Chemical Corporation (JP) 2019-01-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10759815-B2 Condensed heterocyclic compounds and pesticides NR4A1, CHRM1, NR1D2 HTT 1169/4885SLC2A1 2019/4885MAT2A 3010/4885
US-20200223868-A1 CONDENSED HETEROCLYCLIC COMPOUNDS AND PESTICIDES CHRM1, HCRTR1, NR4A1 HTT 1338/4885SLC2A1 703/4885MAT2A 3745/4885
US-10544163-B2 Condensed heterocyclic compounds and pesticides NR4A1, CHRM1, NR1D2 HTT 1214/4885SLC2A1 2083/4885MAT2A 2981/4885
US-20200095263-A1 CONDENSED HETEROCYCLIC COMPOUNDS AND PESTICIDES NR4A1, CHRM1, NR1D2 HTT 1214/4885SLC2A1 2083/4885MAT2A 2981/4885
US-10640518-B2 Condensed heterocyclic compounds and pesticides NR4A1, CHRM1, NR1D2 HTT 1258/4885SLC2A1 2018/4885MAT2A 2968/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.