Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20904051 | 0.87 | OPRM1 (0.59) | OPRM1OPRL1OPRK1 | |
| SCHEMBL20647558 | 0.82 | OPRM1 (0.43) | OPRM1OPRL1OPRK1 | |
| SCHEMBL22556047 | 0.80 | OPRM1 (0.53) | OPRM1OPRL1OPRK1 | |
| SCHEMBL20647601 | 0.77 | CRBN (0.40) | OPRM1OPRL1BRD4 | |
| SCHEMBL20647623 | 0.77 | CRBN (0.40) | OPRM1OPRL1BRD4 | |
| SCHEMBL20640247 | 0.77 | CRBN (0.40) | OPRM1OPRL1BRD4 | |
| SCHEMBL20653858 | 0.77 | OPRM1 (0.39) | OPRM1OPRL1 | |
| SCHEMBL23316659 | 0.74 | OPRM1 (0.36) | OPRM1OPRL1 | |
| SCHEMBL23778511 | 0.72 | OPRM1 (0.42) | OPRM1OPRL1 | |
| SCHEMBL5643934 | 0.72 | OPRM1 (0.42) | OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3652157-B1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2021-05-05 | — | — | EP | disclosed |
| EP-3652157-B1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2021-05-05 | — | — | EP | disclosed |
| US-20200331864-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2020-10-22 | — | — | US | disclosed |
| US-20200331864-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2020-10-22 | — | — | US | disclosed |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | Grünenthal GmbH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | Grünenthal GmbH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20190016685-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2019-01-17 | — | — | US | disclosed |
| WO-2019012037-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2019-01-17 | — | — | WO | disclosed |
| US-20190016685-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2019-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190016685-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | OPRK1, OPRD1, OPRL1 | OPRM1 5/4885OPRL1 3/4885OPRK1 1/4885 |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | OPRK1, OPRD1, OPRL1 | OPRM1 5/4885OPRL1 3/4885OPRK1 1/4885 |
| US-20200331864-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | OPRK1, OPRD1, OPRL1 | OPRM1 5/4885OPRL1 3/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.