Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | CASP5 | P51878 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20640307 | 1.00 | LMNA (0.43) | LMNASMN1; SMN2MAPTCHRM5ADRA2C | |
| SCHEMBL20640319 | 0.82 | LMNA (0.41) | LMNASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL20640322 | 0.82 | LMNA (0.41) | LMNASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL20648951 | 0.80 | SCN1A (0.36) | LMNACHRM5ADRA2CACHECASP1 | |
| SCHEMBL24937441 | 0.80 | MAPT (0.50) | LMNASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL20640312 | 0.77 | DRD4 (0.48) | LMNASMN1; SMN2MAPTACHE | |
| Hydrochloric Acid SCHEMBL21875692 | 0.77 | LMNA (0.41) | LMNASMN1; SMN2MAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL21875693 | 0.77 | LMNA (0.41) | LMNASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL20640308 | 0.73 | MAPT (0.44) | LMNASMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL20640300 | 0.72 | LMNA (0.37) | LMNASMN1; SMN2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3652177-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2020-05-20 | — | — | EP | disclosed |
| WO-2019011715-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-01-17 | — | — | WO | disclosed |