Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP4 | P49662 | 1/20 | 0.33 |
| ▸ | CASP5 | P51878 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20640325 | 0.80 | LMNA (0.43) | NPC1LMNAHTTRAB9ACASP1 | |
| SCHEMBL20640307 | 0.80 | LMNA (0.43) | NPC1LMNAHTTRAB9ACASP1 | |
| SCHEMBL20649124 | 0.75 | F2 (0.32) | MEN1NPC1LMNAHTTRAB9A | |
| SCHEMBL7718051 | 0.65 | SMN1; SMN2 (0.35) | MEN1NPC1LMNAHTTRAB9A | |
| SCHEMBL20640322 | 0.63 | LMNA (0.41) | NPC1LMNAHTTRAB9AOPRM1 | |
| SCHEMBL20640319 | 0.63 | LMNA (0.41) | NPC1LMNAHTTRAB9AOPRM1 | |
| SCHEMBL29951538 | 0.62 | SMN1; SMN2 (0.37) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL9050304 | 0.62 | SMN1; SMN2 (0.56) | MEN1NPC1LMNARAB9AKMT2A | |
| SCHEMBL20649096 | 0.62 | GPR119 (0.51) | KMT2A | |
| SCHEMBL20640306 | 0.60 | LMNA (0.46) | CNR1CNR2MEN1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019011715-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-01-17 | — | — | WO | disclosed |