Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 2/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30437703 | 1.00 | NLRP3 (0.62) | NLRP3NOTUMLRRK2MPOCAPN1 | |
| SCHEMBL20651722 | 0.80 | NLRP3 (0.76) | NLRP3NOTUMLRRK2MPOCYP3A4 | |
| SCHEMBL20641899 | 0.79 | NLRP3 (0.71) | NLRP3NOTUMLRRK2MPOCYP3A4 | |
| SCHEMBL25400986 | 0.78 | NOTUM (0.51) | NLRP3NOTUMLRRK2CAPN1CYP3A4 | |
| SCHEMBL30437871 | 0.78 | NLRP3 (0.55) | NLRP3NOTUMLRRK2MPOKDM4E | |
| SCHEMBL30437860 | 0.77 | NLRP3 (0.58) | NLRP3NOTUMLRRK2MPOCYP3A4 | |
| SCHEMBL20641800 | 0.77 | NLRP3 (0.58) | NLRP3NOTUMLRRK2MPOCYP3A4 | |
| SCHEMBL20651719 | 0.75 | NLRP3 (0.77) | NLRP3LRRK2MPOCYP3A4 | |
| SCHEMBL20642043 | 0.74 | NLRP3 (0.55) | NLRP3NOTUMLRRK2MPOCYP3A4 | |
| SCHEMBL2033116 | 0.74 | NOTUM (0.58) | NLRP3NOTUMCAPN1CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12171756-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC. (US) | 2024-12-24 | — | — | US | disclosed |
| EP-3652166-B1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY INC (US) | 2024-11-20 | — | — | EP | disclosed |
| CN-111793060-B | NLRP3 modulators | 先天肿瘤免疫公司 | 2023-06-06 | — | — | CN | disclosed |
| US-20220257587-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY INC (US) | 2022-08-18 | — | — | US | disclosed |
| US-11344543-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-11344543-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| CN-111793060-A | NLRP3 modulators | 先天肿瘤免疫公司 | 2020-10-20 | — | — | CN | disclosed |
| EP-3652166-A1 | NLRP3 MODULATORS | Innate Tumor Immunity, Inc. (US) | 2020-05-20 | — | — | EP | disclosed |
| US-20200129500-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY INC (US) | 2020-04-30 | — | — | US | disclosed |
| CN-110914258-A | NLRP3 modulators | 先天肿瘤免疫公司 | 2020-03-24 | — | — | CN | disclosed |
| WO-2019014402-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY, INC. (US) | 2019-01-17 | — | — | WO | disclosed |
| WO-2019014402-A1 | NLRP3 MODULATORS | INNATE TUMOR IMMUNITY, INC. (US) | 2019-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200129500-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, PYCARD | NLRP3 1/4885NOTUM 4277/4885LRRK2 714/4885 |
| US-20220257587-A1 | NLRP3 MODULATORS | NLRP3, NLRP1, PYCARD | NLRP3 1/4885NOTUM 4270/4885LRRK2 686/4885 |
| US-11344543-B2 | NLRP3 modulators | NLRP3, NLRP1, PYCARD | NLRP3 1/4885NOTUM 4277/4885LRRK2 714/4885 |
| US-12171756-B2 | NLRP3 modulators | NLRP3, NLRP1, PYCARD | NLRP3 1/4885NOTUM 4270/4885LRRK2 686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.