Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20645596 | 0.84 | HPGD (0.46) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3589251 | 0.82 | HPGD (0.47) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3082319 | 0.80 | ALDH1A1 (0.48) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL564714 | 0.79 | HPGD (0.43) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3803808 | 0.79 | NPC1 (0.43) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13310628 | 0.77 | SSTR4 (0.43) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3432978 | 0.75 | NPC1 (0.43) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL249966 | 0.75 | L3MBTL1 (0.49) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31528291 | 0.74 | SSTR4 (0.49) | ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8776818 | 0.72 | CYP11B1 (0.48) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359547-B1 | Pyridine compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL (JP) | 1996-01-24 | — | — | EP | disclosed |
| EP-0558094-A1 | Pyridine compounds for treating amnesia | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |
| US-5001137-A | Pyridine compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-03-19 | — | — | US | disclosed |
| EP-0359547-A1 | Pyridine compounds and pharmaceutical use thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1990-03-21 | — | — | EP | disclosed |