Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139339 | 0.89 | HPGD (0.48) | USP2SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL28885252 | 0.81 | USP2 (0.62) | USP2SMN1; SMN2HPGDGRM5GPR119 | |
| SCHEMBL28340156 | 0.78 | USP2 (0.56) | USP2SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL18294 | 0.77 | USP2 (0.69) | USP2SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL698803 | 0.77 | USP2 (0.69) | USP2SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL1711601 | 0.76 | USP2 (0.55) | USP2SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL21599183 | 0.76 | MEN1 (0.51) | USP2SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL27388627 | 0.75 | USP2 (0.62) | USP2SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL16612394 | 0.75 | USP2 (0.62) | USP2SMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL13901502 | 0.75 | HPGD (0.47) | USP2SMN1; SMN2MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019011217-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS OR PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF AND USE THEREOF | 中国科学院上海药物研究所 | 2019-01-17 | — | — | WO | disclosed |