Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20645659 | 0.89 | USP2 (0.46) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL28885252 | 0.88 | USP2 (0.62) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL24673913 | 0.81 | USP2 (0.51) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL10253506 | 0.81 | USP2 (0.51) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL513246 | 0.80 | USP2 (0.50) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL30897992 | 0.80 | USP2 (0.50) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL13901502 | 0.79 | HPGD (0.47) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL18537691 | 0.79 | HPGD (0.47) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL843458 | 0.79 | USP2 (0.49) | HPGDUSP2SMN1; SMN2GRM5GPR119 | |
| SCHEMBL1689676 | 0.79 | USP2 (0.49) | HPGDUSP2SMN1; SMN2GRM5GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708365-B2 | Processes for preparing TPH1 inhibitors | ALTAVANT SCIENCES GMBH | 2023-07-25 | — | — | US | disclosed |
| US-11708365-B2 | Processes for preparing TPH1 inhibitors | ALTAVANT SCIENCES GMBH | 2023-07-25 | — | — | US | disclosed |
| US-11708365-B2 | Processes for preparing TPH1 inhibitors | ALTAVANT SCIENCES GMBH | 2023-07-25 | — | — | US | disclosed |
| CN-115536661-A | Resolution of optically active diazaspiro [4.5] decane derivatives | 奥塔万特科学股份有限公司 | 2022-12-30 | — | — | CN | disclosed |
| CN-110177790-B | Resolution of optically active diazaspiro [4.5] decane derivatives | 奥塔万特科学股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| EP-3538530-B1 | RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES | ALTAVANT SCIENCES GMBH (CH) | 2022-01-05 | — | — | EP | disclosed |
| EP-3538530-B1 | RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES | ALTAVANT SCIENCES GMBH (CH) | 2022-01-05 | — | — | EP | disclosed |
| US-20210139481-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2021-05-13 | — | — | US | disclosed |
| US-20210139481-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2021-05-13 | — | — | US | disclosed |
| EP-3538530-A1 | RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES | Altavant Sciences GmbH (CH) | 2019-09-18 | — | — | EP | disclosed |
| US-20190263815-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2019-08-29 | — | — | US | disclosed |
| US-20190263815-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | ALTAVANT SCIENCES GMBH (CH) | 2019-08-29 | — | — | US | disclosed |
| WO-2018087602-A1 | RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES | ROIVANT SCIENCES GMBH (CH) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018087602-A1 | RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES | ROIVANT SCIENCES GMBH (CH) | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190263815-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | TPH1, TPH2, HTR1A | HPGD 115/4885USP2 2513/4885SMN1; SMN2 3676/4885 |
| US-11708365-B2 | Processes for preparing TPH1 inhibitors | TPH1, TPH2, HTR1A | HPGD 115/4885USP2 2424/4885SMN1; SMN2 3656/4885 |
| US-20210139481-A1 | PROCESSES FOR PREPARING TPH1 INHIBITORS | TPH1, TPH2, HTR1A | HPGD 115/4885USP2 2424/4885SMN1; SMN2 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.