Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CFTR | P13569 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19104464 | 0.77 | MAPT (0.32) | — | |
| SCHEMBL17395669 | 0.68 | DRD2 (0.33) | — | |
| SCHEMBL17616387 | 0.67 | NPSR1 (0.40) | KMT2AHSD17B10TSHR | |
| SCHEMBL29127877 | 0.65 | KDM4E (0.36) | HSD17B10CFTRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22077234 | 0.65 | SLC6A3 (0.40) | — | |
| SCHEMBL22092595 | 0.65 | SLC6A3 (0.40) | — | |
| SCHEMBL25839939 | 0.65 | — | — | |
| SCHEMBL20646209 | 0.64 | — | — | |
| SCHEMBL11147814 | 0.63 | SLC6A3 (0.41) | HSD17B10 | |
| SCHEMBL17395732 | 0.63 | METAP2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164396-B1 | CYCLOHEXEN-1-YL-PYRIDIN-2-YL-1H-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | NOVARTIS AG (CH) | 2019-01-16 | — | — | EP | disclosed |