SCHEMBL20647697

SCHEMBL20647697

CCCCc1nc2c(N)nc3ccccc3c2n1CCCCNC(C)(C)C

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.74
TLR8 Q9NR97 12/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20801448 0.99 TLR7 (0.73) TLR7TLR8
SCHEMBL14516517 0.89 TLR7 (0.78) TLR7TLR8
SCHEMBL18610180 0.89 TLR7 (0.78) TLR7TLR8
SCHEMBL18646318 0.89 TLR7 (0.78) TLR7TLR8
SCHEMBL20623370 0.88 TLR7 (0.89) TLR7TLR8
SCHEMBL22536886 0.87 TLR7 (0.82) TLR7TLR8
SCHEMBL25574264 0.87 TLR7 (0.76) TLR7TLR8
SCHEMBL20801426 0.87 TLR7 (0.76) TLR7TLR8
SCHEMBL20647761 0.86 TLR7 (0.68) TLR7TLR8
SCHEMBL18646022 0.86 TLR7 (0.84) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230201355-A1 IL-2 SEQUENCES AND USES THEREOF Ascendis Pharma Oncology Division A/S (DK) 2023-06-29 US disclosed
US-20230174605-A1 IL-2 SEQUENCES AND USES THEREOF Ascendis Pharma Oncology Division A/S (DK) 2023-06-08 US disclosed
US-11547761-B1 Antibody adjuvant conjugates THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2023-01-10 US disclosed
US-20210284750-A1 Immunoconjugate Synthesis Method BOLT BIOTHERAPEUTICS, INC. (US) 2021-09-16 US disclosed
US-11110178-B2 Antibody adjuvant conjugates THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY (US) 2021-09-07 US disclosed
US-20200206357-A1 ANTIBODY ADJUVANT CONJUGATES BOLT BIOTHERAPEUTICS, INC. 2020-07-02 US disclosed
US-10675358-B2 Antibody adjuvant conjugates THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2020-06-09 US disclosed
US-20200140556-A1 Methods and Compositions for Dectin-2 Stimulation and Cancer Immunotherapy HOWARD HUGHES MEDICAL INSTITUTE 2020-05-07 US disclosed
US-20190076547-A1 ANTIBODY ADJUVANT CONJUGATES BOLT BIOTHERAPEUTICS, INC. 2019-03-14 US disclosed
US-20190015516-A1 ANTIBODY ADJUVANT CONJUGATES BOLT BIOTHERAPEUTICS, INC. (US) 2019-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230201355-A1 IL-2 SEQUENCES AND USES THEREOF IL2, IL2RA, IL4I1 TLR7 3887/4885TLR8 3502/4885
US-20200206357-A1 ANTIBODY ADJUVANT CONJUGATES FCGR1A, FCGR3B, FCGR2A TLR7 58/4885TLR8 56/4885
US-10675358-B2 Antibody adjuvant conjugates FCGR1A, FCGR3B, FCGR2A TLR7 58/4885TLR8 56/4885
US-20190015516-A1 ANTIBODY ADJUVANT CONJUGATES FCGR1A, FCGR3B, FCGR2A TLR7 121/4885TLR8 99/4885
US-20200140556-A1 Methods and Compositions for Dectin-2 Stimulation and Cancer Immunotherapy TLR2, TLR8, TLR3 TLR7 4/4885TLR8 2/4885
US-20190076547-A1 ANTIBODY ADJUVANT CONJUGATES FCGR1A, FCGR3B, FCGR2A TLR7 57/4885TLR8 59/4885
US-20210284750-A1 Immunoconjugate Synthesis Method FCGR3B, FCGR1A, FCGR2A TLR7 84/4885TLR8 435/4885
US-11547761-B1 Antibody adjuvant conjugates FCGR1A, FCGR3B, FCGR2A TLR7 58/4885TLR8 56/4885
US-20230174605-A1 IL-2 SEQUENCES AND USES THEREOF IL2, IL2RA, IL4I1 TLR7 3887/4885TLR8 3502/4885
US-11110178-B2 Antibody adjuvant conjugates FCGR1A, FCGR3B, FCGR2A TLR7 58/4885TLR8 56/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.