Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20649235 | 0.91 | CDK2 (0.33) | CDK2AURKACCNA2CCNA1 | |
| SCHEMBL20649268 | 0.89 | CDK2 (0.32) | CDK2AURKACCNA2CCNA1 | |
| SCHEMBL20648954 | 0.88 | CDK2 (0.44) | ACVR1CDK2AURKACCNA2CCNA1 | |
| SCHEMBL20649199 | 0.87 | ATR (0.32) | — | |
| SCHEMBL20649041 | 0.87 | PARP1 (0.31) | — | |
| SCHEMBL20649038 | 0.87 | — | — | |
| SCHEMBL20649146 | 0.85 | CALCA (0.31) | — | |
| SCHEMBL20648988 | 0.85 | — | — | |
| SCHEMBL20649387 | 0.85 | — | — | |
| SCHEMBL20649094 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019011715-A1 | PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2019-01-17 | — | — | WO | disclosed |