Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.37 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203686 | 0.83 | MKNK1 (0.46) | TNFMKNK1KLK7DYRK1APRMT5 | |
| SCHEMBL4885869 | 0.73 | CDK1 (0.44) | TNFMKNK1KLK7DYRK1ACA1 | |
| SCHEMBL2392859 | 0.72 | MKNK1 (0.53) | MKNK1KLK7DYRK1APRMT5WDR77 | |
| SCHEMBL2065978 | 0.71 | TNF (0.67) | TNFCA1CA2CA9CA12 | |
| Hydrochloric Acid SCHEMBL16324142 | 0.71 | MKNK1 (0.51) | MKNK1KLK7DYRK1APRMT5WDR77 | |
| SCHEMBL454803 | 0.70 | TGFBR1 (0.48) | MKNK1KLK7DYRK1ATGFBR1SSTR4 | |
| SCHEMBL9525882 | 0.70 | TGFBR1 (0.46) | TNFTGFBR1ALDH1A1 | |
| SCHEMBL16256010 | 0.69 | MKNK1 (0.50) | MKNK1KLK7DYRK1APRMT5WDR77 | |
| SCHEMBL477032 | 0.68 | MKNK1 (0.53) | MKNK1KLK7DYRK1APRMT5WDR77 | |
| SCHEMBL22510132 | 0.68 | MKNK1 (0.53) | MKNK1KLK7DYRK1APRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436955-A1 | SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS | Lario Therapeutics Limited (GB) | 2024-10-02 | — | — | EP | disclosed |
| CN-118317950-A | Sulfonamide compounds for the treatment of neurological disorders | 拉里奥治疗有限公司 | 2024-07-09 | — | — | CN | disclosed |
| WO-2023094830-A1 | SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS | LARIO THERAPEUTICS LIMITED (GB) | 2023-06-01 | — | — | WO | disclosed |
| US-8148524-B2 | Process for producing sulfonyl chloride compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-04-03 | — | — | US | disclosed |
| EP-1932846-B1 | METHOD FOR PRODUCING SULFONYL CHLORIDE COMPOUND | SUMITOMO CHEMICAL CO (JP) | 2010-10-27 | — | — | EP | disclosed |
| JP-2010143944-A | NEW METHOD FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINES | SUMITOMO CHEMICAL CO LTD | 2010-07-01 | — | — | JP | disclosed |
| EP-1541575-B1 | NOVEL PROCESS FOR PRODUCING IMIDAZO(1,2-B)PYRIDAZINE DERIVATIVE | SUMITOMO CHEMICAL CO (JP) | 2010-03-03 | — | — | EP | disclosed |
| US-20090247748-A1 | PROCESS FOR PRODUCING SULFONYL CHLORIDE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-10-01 | — | — | US | disclosed |
| EP-1932846-A1 | METHOD FOR PRODUCING SULFONYL CHLORIDE COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2008-06-18 | — | — | EP | disclosed |
| US-7307165-B2 | Process for producting imidazo[1,2-b]pyridazine derivative | SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) | 2007-12-11 | — | — | US | disclosed |
| US-7307165-B2 | Process for producting imidazo[1,2-b]pyridazine derivative | SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) | 2007-12-11 | — | — | US | disclosed |
| CN-100341875-C | Novel process for producting imidazo[1,2-b]pyridazine derivative | SUMITOMO CHEM TAKEDA AGRO CO (JP) | 2007-10-10 | — | — | CN | disclosed |
| EP-1541575-A4 | NOVEL PROCESS FOR PRODUCING IMIDAZO(1,2-B)PYRIDAZINE DERIVATIVE | SUMITOMO CHEM TAKEDA AGRO CO (JP) | 2007-02-28 | — | — | EP | disclosed |
| CN-1671707-A | Novel process for producting imidazo[1,2-b]pyridazine derivative | SUMITOMO CHEM TAKEDA AGRO CO (JP) | 2005-09-21 | — | — | CN | disclosed |
| US-20050171108-A1 | Novel process for producting imidazo[1,2-b]pyridazine derivative | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-08-04 | — | — | US | disclosed |
| US-20050171108-A1 | Novel process for producting imidazo[1,2-b]pyridazine derivative | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-08-04 | — | — | US | disclosed |
| EP-1541575-A1 | NOVEL PROCESS FOR PRODUCING IMIDAZO(1,2-B)PYRIDAZINE DERIVATIVE | Sumitomo Chemical Takeda Agro Company, Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-1541575-A1 | NOVEL PROCESS FOR PRODUCING IMIDAZO(1,2-B)PYRIDAZINE DERIVATIVE | Sumitomo Chemical Takeda Agro Company, Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004011466-A1 | NOVEL PROCESS FOR PRODUCING IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVE | SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) | 2004-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171108-A1 | Novel process for producting imidazo[1,2-b]pyridazine derivative | POR, CBR3, NR2C2 | TNF 4860/4885MKNK1 3298/4885KLK7 4439/4885 |
| US-20090247748-A1 | PROCESS FOR PRODUCING SULFONYL CHLORIDE COMPOUND | SALL4, CLCN2, CLIC1 | TNF 4785/4885MKNK1 3848/4885KLK7 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.