Sugi Predict

Sugi Predict / Compounds / SCHEMBL2065084

SCHEMBL2065084

SCHEMBL2065084

CC(C)(C)OC(=O)N1C[C@@H]2CN(c3cncc(Cl)n3)C[C@@H]2C1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 8/20 0.46
▸ PDE10A Q9Y233 2/20 0.46
▸ NR1H2 P55055 1/20 0.42
▸ KCNK3 O14649 1/20 0.41
▸ KCNK9 Q9NPC2 1/20 0.41
▸ CKS1B P61024 1/20 0.40
▸ SKP1 P63208 1/20 0.40
▸ SKP2 Q13309 1/20 0.40
▸ OPRM1 P35372 1/20 0.39
▸ OPRD1 P41143 1/20 0.39
▸ OPRK1 P41145 1/20 0.39
▸ OGFRL1 Q5TC84 1/20 0.39
▸ HCRTR1 O43613 2/20 0.39
▸ HCRTR2 O43614 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ HTR1A P08908 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2065083 1.00 GPR119 (0.46) GPR119PDE10ANR1H2KCNK3KCNK9
SCHEMBL6735301 0.88 GPR119 (0.42) GPR119PDE10ANR1H2CKS1BSKP1
SCHEMBL4107518 0.85 GPR119 (0.39) GPR119PDE10ANR1H2CKS1BSKP1
SCHEMBL4107514 0.85 GPR119 (0.39) GPR119PDE10ANR1H2CKS1BSKP1
SCHEMBL2064751 0.84 RBP4 (0.48) GPR119PDE10ANR1H2CKS1BSKP1
SCHEMBL38664503 0.84 GPR119 (0.46) GPR119CKS1BSKP1SKP2OPRM1
SCHEMBL1432444 0.84 CKS1B (0.56) GPR119CKS1BSKP1SKP2KDM4E
SCHEMBL3486232 0.83 GPR119 (0.68) GPR119CKS1BSKP1SKP2
SCHEMBL3808153 0.82 CKS1B (0.55) GPR119CKS1BSKP1SKP2KDM4E
SCHEMBL2065518 0.82 GPR119 (0.44) GPR119PDE10ANR1H2CKS1BSKP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106389-A1 NMT INHIBITOR AND USE THEREOF 주식회사 이노보테라퓨틱스 2026-05-21 — — WO disclosed
EP-2700639-A1 Selective ligands for the neuronal nicotinic receptors and uses thereof Abbvie Inc. (US) 2014-02-26 — — EP disclosed
US-8648084-B2 Selective substituted pyrazine ligands for neuronal nicotinic receptors ABBVIE INC. (US) 2014-02-11 — — US disclosed
US-20120190692-A1 SELECTIVE SUBSTITUTED PYRIDINE LIGANDS FOR NEURONAL NICOTINIC RECEPTORS ABBVIE INC. 2012-07-26 — — US disclosed
US-8148408-B2 Selective substituted pyridine ligands for neuronal nicotinic receptors ABBOTT LABORATORIES (US) 2012-04-03 — — US disclosed
US-20090281118-A1 Selective Ligands for the Neuronal Nicotinic Receptors and Uses Thereof ABBOTT LABORATORIES (US) 2009-11-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190692-A1 SELECTIVE SUBSTITUTED PYRIDINE LIGANDS FOR NEURONAL NICOTINIC RECEPTORS CHRNA4, CHRNB4, CHRNA2 GPR119 102/4885PDE10A 2610/4885NR1H2 326/4885
US-20090281118-A1 Selective Ligands for the Neuronal Nicotinic Receptors and Uses Thereof CHRNA4, CHRNB4, CHRNA2 GPR119 76/4885PDE10A 2131/4885NR1H2 264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.