Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065090 | 1.00 | ESR1 (0.32) | ESR1ESR2HSD11B1CNR1CHRNA7 | |
| SCHEMBL1091864 | 0.88 | DBH (0.32) | CNR1 | |
| SCHEMBL1091860 | 0.88 | DBH (0.32) | CNR1 | |
| SCHEMBL1092616 | 0.87 | KDM4E (0.33) | — | |
| SCHEMBL1092613 | 0.87 | KDM4E (0.33) | — | |
| SCHEMBL4514217 | 0.84 | KMT2A (0.41) | HSD11B1CHRNA7 | |
| SCHEMBL4517686 | 0.84 | CYP26A1 (0.35) | ESR1ESR2HSD11B1CHRNA7 | |
| Hydrochloric Acid SCHEMBL2065245 | 0.83 | ALDH1A1 (0.34) | CNR1CHRNA7 | |
| Hydrochloric Acid SCHEMBL2065599 | 0.83 | ALDH1A1 (0.34) | CNR1CHRNA7 | |
| SCHEMBL2065488 | 0.81 | PDE4D (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016071-B1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2013-07-24 | — | — | EP | disclosed |
| US-8148534-B2 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 | ELI LILLY AND COMPANY (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090275613-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275613-A1 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD11B2, HSD3B1 | ESR1 1672/4885ESR2 1632/4885HSD11B1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.