Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 6/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 8/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21311550 | 0.84 | CRBN (0.49) | HTR2BHTR2CHTR2ACRBNIKZF3 | |
| SCHEMBL23418102 | 0.84 | CRBN (0.43) | HTR2BHTR2CHTR2ACRBNIKZF3 | |
| SCHEMBL21480839 | 0.81 | CRBN (0.62) | HTR2BHTR2CHTR2ACRBNIKZF3 | |
| SCHEMBL22733298 | 0.81 | CRBN (0.49) | HTR2BHTR2CHTR2ACRBNIKZF3 | |
| SCHEMBL27097876 | 0.81 | CRBN (0.62) | HTR2BHTR2CHTR2ACRBNIKZF3 | |
| SCHEMBL23418179 | 0.81 | CRBN (0.45) | HTR2BHTR2CHTR2ACRBNIKZF3 | |
| SCHEMBL23319245 | 0.81 | CRBN (0.47) | HTR2BHTR2CHTR2ACRBNIKZF3 | |
| SCHEMBL25524508 | 0.81 | CRBN (0.47) | HTR2BHTR2CHTR2ACRBNIKZF3 | |
| SCHEMBL3542188 | 0.79 | CRBN (0.70) | CRBNIKZF3BRD4TNFIL1B | |
| SCHEMBL21303951 | 0.79 | CRBN (0.70) | CRBNIKZF3BRD4TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019014429-A1 | COMPOUNDS FOR TAU PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-01-17 | — | — | WO | disclosed |