Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 4/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | IL1B | P01584 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 8/20 | 0.38 |
| ▸ | HTR2A | P28223 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27097876 | 0.85 | CRBN (0.62) | CRBNIKZF3IKZF1BRD4TNF | |
| SCHEMBL21480839 | 0.85 | CRBN (0.62) | CRBNIKZF3IKZF1BRD4TNF | |
| SCHEMBL21311550 | 0.85 | CRBN (0.49) | CRBNIKZF3IKZF1BRD4TNF | |
| SCHEMBL25524508 | 0.81 | CRBN (0.47) | CRBNIKZF3IKZF1BRD4TNF | |
| SCHEMBL20652629 | 0.81 | HTR2B (0.53) | CRBNIKZF3IKZF1BRD4TNF | |
| SCHEMBL23319245 | 0.81 | CRBN (0.47) | CRBNIKZF3IKZF1BRD4TNF | |
| Hydrochloric Acid SCHEMBL31184864 | 0.80 | HTR2B (0.48) | CRBNIKZF3IKZF1BRD4TNF | |
| SCHEMBL30659847 | 0.80 | PARP1 (0.49) | CRBNMAPK1PARP10PARP11HTR2B | |
| SCHEMBL23959034 | 0.79 | CRBN (0.46) | CRBNIKZF3IKZF1BRD4TNF | |
| SCHEMBL20128653 | 0.79 | CRBN (0.62) | CRBNIKZF3DDB1HTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020242960-A1 | COMPOUNDS TARGETING PROTEINS AND PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. (US) | 2020-12-03 | — | — | WO | disclosed |