Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.49 |
| ▸ | HTR2B | P41595 | 8/20 | 0.49 |
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | IL1B | P01584 | 1/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21480839 | 0.85 | CRBN (0.62) | CRBNHTR2BHTR2CHTR2ADDB1 | |
| SCHEMBL27097876 | 0.85 | CRBN (0.62) | CRBNHTR2BHTR2CHTR2ADDB1 | |
| SCHEMBL22733298 | 0.85 | CRBN (0.49) | CRBNHTR2BHTR2CHTR2ADDB1 | |
| SCHEMBL25524508 | 0.84 | CRBN (0.47) | CRBNHTR2BHTR2CHTR2ADDB1 | |
| SCHEMBL20652629 | 0.84 | HTR2B (0.53) | CRBNHTR2BHTR2CHTR2ADDB1 | |
| SCHEMBL23319245 | 0.84 | CRBN (0.47) | CRBNHTR2BHTR2CHTR2ADDB1 | |
| SCHEMBL23959034 | 0.81 | CRBN (0.46) | CRBNHTR2BHTR2CHTR2ADDB1 | |
| SCHEMBL25671252 | 0.80 | CRBN (0.47) | CRBNDDB1IKZF3BRD4TNF | |
| SCHEMBL20128653 | 0.79 | CRBN (0.62) | CRBNHTR2BHTR2CHTR2ADDB1 | |
| SCHEMBL23418102 | 0.78 | CRBN (0.43) | CRBNHTR2BHTR2CHTR2ADDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795570-A1 | SUBSTITUTED QUINOLINE-8-CARBONITRILE DERIVATIVES HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF | Accutar Biotechnology Inc. (US) | 2021-03-24 | — | — | EP | disclosed |
| WO-2020263935-A1 | HCK DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020219650-A1 | DEGRADERS OF CYCLIN-DEPENDENT KINASE 12 (CDK12) AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-10-29 | — | — | WO | disclosed |
| WO-2019165216-A1 | SMALL MOLECULES THAT BLOCK PROTEASOME-ASSOCIATED UBIQUITIN RECEPTOR RPN13 FUNCTION AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-29 | — | — | WO | disclosed |