Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.51 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20639239 | 0.88 | PARP1 (0.50) | HPGDSMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL16398233 | 0.77 | CA1 (0.63) | KMT2AMEN1 | |
| SCHEMBL5974770 | 0.75 | KMT2A (0.73) | HPGDALDH1A1SMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL13210704 | 0.75 | KMT2A (0.81) | HPGDALDH1A1SMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL30998138 | 0.75 | CYP11B2 (0.77) | HPGDALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL330581 | 0.75 | P2RX1 (0.76) | HPGDALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL15917720 | 0.75 | MEN1 (0.61) | HPGDALDH1A1SMN1; SMN2MAPK1RAB9A | |
| SCHEMBL5211749 | 0.75 | RAB9A (0.74) | HPGDALDH1A1SMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL17071867 | 0.75 | POLB (0.43) | HPGDSMN1; SMN2RAB9APOLBNPC1 | |
| SCHEMBL2106312 | 0.74 | CYP11B2 (0.61) | ALDH1A1SMN1; SMN2RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019014352-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-01-17 | — | — | WO | disclosed |