SCHEMBL2065442

SCHEMBL2065442

O=COc1ccc(CC2NCCC3=C2CCCC3)cc1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC22A1 O15245 1/20 0.35
PRCP P42785 1/20 0.35
KDM1A O60341 1/20 0.34
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34
BCHE P06276 2/20 0.33
KDM4E B2RXH2 2/20 0.33
MAPT P10636 2/20 0.33
PKM P14618 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
TBXA2R P21731 2/20 0.33
ACHE P22303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6436095 0.82 BCHE (0.43) DRD2BCHEKDM4EMAPTPKM
SCHEMBL2064742 0.82 BCHE (0.43) DRD2BCHEKDM4EMAPTPKM
Hydrochloric Acid SCHEMBL29199502 0.81 BCHE (0.42) DRD2BCHEKDM4EMAPTPKM
Hydrochloric Acid SCHEMBL11535212 0.81 BCHE (0.42) DRD2BCHEKDM4EMAPTPKM
SCHEMBL11363948 0.80 SLC22A1 (0.44) SLC22A1PRCPKDM4EMAPTPKM
Formic Acid SCHEMBL28231178 0.78 DRD2 (0.36) SLC22A1PRCPKDM1ADRD2DRD4
Formic Acid SCHEMBL28861710 0.78 DRD2 (0.36) SLC22A1PRCPKDM1ADRD2DRD4
SCHEMBL23115291 0.78 SLC22A1 (0.55) SLC22A1PRCPKDM1A
SCHEMBL23115288 0.78 SLC22A1 (0.55) SLC22A1PRCPKDM1A
SCHEMBL23135179 0.78 SLC22A1 (0.55) SLC22A1PRCPKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8148527-B1 Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline Divi's Laboratories, Ltd. (IN) 2012-04-03 US claimed