Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28764676 | 0.80 | DPP4 (0.48) | CYP2A6PDCD1CD274PTGS1PTPRC | |
| SCHEMBL10473041 | 0.78 | CYP2A6 (0.58) | CYP2A6MAPTALDH1A1 | |
| SCHEMBL27691517 | 0.77 | ESR2 (0.45) | CYP2A6PTGS1PTPRCKMT2AMAPT | |
| SCHEMBL8573654 | 0.76 | DPP4 (0.41) | PTGS1KMT2ACES1MAPTKDM4E | |
| SCHEMBL8193897 | 0.76 | CTSA (0.39) | CYP2A6KMT2AMAPK1MAPTKDM4E | |
| SCHEMBL5111011 | 0.75 | TP53 (0.57) | CYP2A6PDCD1CD274PTGS1TP53 | |
| SCHEMBL20991154 | 0.72 | KLF10 (0.34) | CYP2A6PTGS1TP53KMT2AALOX15 | |
| SCHEMBL10550712 | 0.72 | DPP4 (0.41) | PTGS1KMT2ACES1MAPTKDM4E | |
| SCHEMBL5954368 | 0.71 | PTGS1 (0.36) | CYP2A6PTGS1TP53KMT2AALOX15 | |
| SCHEMBL10846409 | 0.70 | PDCD1 (0.34) | PDCD1CD274PTGS1ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200165266-A1 | RING CLOSURE REACTION | FLEXENABLE LIMITED (GB) | 2020-05-28 | — | — | US | disclosed |
| WO-2019011826-A1 | RING CLOSURE REACTION | MERCK PATENT GMBH (DE) | 2019-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165266-A1 | RING CLOSURE REACTION | LIG4, ATG7, RNF4 | CYP2A6 553/4885PDCD1 1599/4885CD274 2198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.