Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.33 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977821 | 0.92 | KDM4E (0.47) | KDM4EPIK3CDNQO2NAAAALDH1A1 | |
| SCHEMBL17162612 | 0.88 | — | — | |
| SCHEMBL4035621 | 0.80 | KDM4E (0.46) | KDM4EPIK3CDNQO2NAAAALDH1A1 | |
| SCHEMBL15111451 | 0.80 | KDM4E (0.46) | KDM4EPIK3CDNQO2NAAAALDH1A1 | |
| SCHEMBL1031978 | 0.80 | KDM4E (0.46) | KDM4EPIK3CDNQO2NAAAALDH1A1 | |
| SCHEMBL4573839 | 0.80 | NAAA (0.49) | KDM4EPIK3CDNQO2NAAAALDH1A1 | |
| SCHEMBL16377754 | 0.80 | KDM4E (0.46) | KDM4EPIK3CDNQO2NAAAALDH1A1 | |
| SCHEMBL31308 | 0.78 | NAAA (0.51) | KDM4EPIK3CDNQO2NAAAALDH1A1 | |
| SCHEMBL10981200 | 0.78 | KDM4E (0.45) | KDM4EPIK3CDNQO2NAAAALDH1A1 | |
| SCHEMBL4860823 | 0.77 | NAAA (0.54) | KDM4EPIK3CDNAAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327017-B1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | MERCK PATENT GMBH (DE) | 2019-04-24 | — | — | EP | disclosed |
| EP-3327017-B1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | MERCK PATENT GMBH (DE) | 2019-04-24 | — | — | EP | disclosed |
| US-10183935-B2 | Benzamide derivatives as modulators of the follicle stimulating hormone | MERCK PATENT GMBH (DE) | 2019-01-22 | — | — | US | disclosed |
| US-10183935-B2 | Benzamide derivatives as modulators of the follicle stimulating hormone | MERCK PATENT GMBH (DE) | 2019-01-22 | — | — | US | disclosed |
| EP-3327017-A1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | Merck Patent GmbH (DE) | 2018-05-30 | — | — | EP | disclosed |
| EP-3327017-A1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | Merck Patent GmbH (DE) | 2018-05-30 | — | — | EP | disclosed |
| EP-2802575-B1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | MERCK PATENT GMBH (DE) | 2017-12-27 | — | — | EP | disclosed |
| EP-2802575-B1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | MERCK PATENT GMBH (DE) | 2017-12-27 | — | — | EP | disclosed |
| US-20170226096-A1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | MERCK PATENT GMBH (DE) | 2017-08-10 | — | — | US | disclosed |
| US-20170226096-A1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | MERCK PATENT GMBH (DE) | 2017-08-10 | — | — | US | disclosed |
| WO-2013106409-A1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | WO | disclosed |
| US-8357524-B2 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | DANISCO US INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20120295329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-11-22 | — | — | US | disclosed |
| US-20120156721-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | US | disclosed |
| US-8148128-B2 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-04-03 | — | — | US | disclosed |
| EP-1129180-B1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | UNIV TORONTO (CA) | 2009-06-10 | — | — | EP | disclosed |
| US-20090075329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2009-03-19 | — | — | US | disclosed |
| US-20050282248-A1 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | JONES JOHN B | 2005-12-22 | — | — | US | disclosed |
| EP-1129180-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000028007-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2000-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226096-A1 | BENZAMIDE DERIVATIVES AS MODULATORS OF THE FOLLICLE STIMULATING HORMONE | FSHR, GNRHR, SHBG | KDM4E 1708/4885PIK3CD 2977/4885NQO2 980/4885 |
| US-10183935-B2 | Benzamide derivatives as modulators of the follicle stimulating hormone | FSHR, GNRHR, SHBG | KDM4E 1708/4885PIK3CD 2977/4885NQO2 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.